p600 Plays Essential Roles in Fetal Development

p600 Plays Essential Roles in Fetal Development

p600 is a multifunctional protein implicated in cytoskeletal organization, integrin-mediated survival signaling, calcium-calmodulin signaling and the N-end rule pathway of ubiquitin-proteasome-mediated proteolysis. While push, the Drosophila counterpart of p600, is dispensable for development up to adult stage, the role of p600 has not been studied during mouse development. Here we generated p6...

03-P099 EPB41L5 plays essential roles in EMT

Embryonic wound healing is both a mechanical process, driven by intraand intercellular forces, and a genetic process, regulated by an array of signalling molecules. Our goal is to understand the fundamental biology and dynamics of embryonic wound healing – to connect the phenomenology of wound-margin shortening to the underlying cytoskeletal mechanics and genetic regulatory networks. As a model...

Essential Roles in Macrophage Chemotaxis Urokinase-Type Plasminogen Activator Plays

NCP1/AtMOB1A Plays Key Roles in Auxin-Mediated Arabidopsis Development.

MOB1 protein is a core component of the Hippo signaling pathway in animals where it is involved in controlling tissue growth and tumor suppression. Plant MOB1 proteins display high sequence homology to animal MOB1 proteins, but little is known regarding their role in plant growth and development. Herein we report the critical roles of Arabidopsis MOB1 (AtMOB1A) in auxin-mediated development in ...

Rhodopsin plays an essential structural role in Drosophila photoreceptor development.

Null mutations of the Drosophila Rh1 rhodopsin gene, ninaE, result in developmental defects in the photosensitive membranes, the rhabdomeres, of compound eye photoreceptors R1-R6. In normal flies, Rh1 expression begins at about 78% of pupal life. At approximately 90% of pupal life, a specialized catacomb-like membrane architecture develops at the base of normal rhabdomeres. In ninaE null mutant...